He hui noiʻi i alakaʻi ʻia e Prof. XUE Tian a me Prof. MA Yuqian mai ke Kulanui o ʻEpekema a me ʻenehana o Kina (USTC), me ka hui pū ʻana me nā hui noiʻi lehulehu, ua hoʻopōmaikaʻi i ke kanaka kokoke-infrared (NIR) spatiotemporal color vision ma o upconversion contact lenses (UCLs). Ua paʻi ʻia ke aʻo ʻana ma ka pūnaewele ma Cell ma Mei 22, 2025 (EST), a ua hōʻike ʻia ma kahi nūhou i hoʻokuʻu ʻia ePaʻi Kelepona.
Ma ke ʻano, ʻo nā hawewe electromagnetic ka lōʻihi o ka nalu, akā hiki i ka maka o ke kanaka ke ʻike i kahi ʻāpana haiki i ʻike ʻia he kukui ʻike ʻia, e hana ana i ka kukui NIR ma mua o ka ʻulaʻula o ka spectrum i ʻike ʻole ʻia e mākou.
Fig1. Nā hawewe electromagnetic a me ke kiko uila ʻike ʻia (Kiʻi mai ka hui o Prof. XUE)
I ka makahiki 2019, ua loaʻa i kahi hui i alakaʻi ʻia e Prof. XUE Tian, MA Yuqian, a me HAN Gang i kahi holomua ma ka hoʻokomo ʻana i nā nanomaterials upconversion i loko o nā retina o nā holoholona, e hiki ai i ka hiki ke ʻike maka kiʻi NIR mua loa i nā mammals. Eia nō naʻe, ma muli o ka liʻiliʻi o ka hoʻohana ʻana o ka intravitreal injection i loko o ke kanaka, ʻo ka pahuhopu nui o kēia ʻenehana aia i ka ʻae ʻana i ka ʻike kanaka i ka mālamalama NIR ma o nā ala non-invasive.
Hāʻawi ʻia nā lens contact transparent palupalu i hana ʻia me nā polymer composites i kahi hopena hiki ke hoʻohana ʻia, akā ʻo ka hoʻomohala ʻana i nā UCL ke alo nei i ʻelua mau pilikia nui: ka loaʻa ʻana o ka hiki ke hoʻololi hou ʻia, e koi ana i ka doping kiʻekiʻe upconversion nanoparticles (UCNPs), a me ka mālama ʻana i ke aniani kiʻekiʻe. Eia nō naʻe, ʻo ka hoʻokomo ʻana i nā nanoparticles i loko o nā polymers e hoʻololi i kā lākou mau waiwai optical, e paʻakikī ai ke kaulike ʻana i ka manaʻo kiʻekiʻe me ka mālamalama optical.
Ma o ka hoʻololi ʻana i ka ʻili o nā UCNP a me ka nānā ʻana i nā mea polymeric i hoʻohālikelike ʻia i ka refractive-index-matched, ua hoʻomohala nā mea noiʻi i nā UCL e loaʻa ana i ka 7-9% UCNP hoʻohui me ka mālama ʻana ma luna o 90% transparency i ka spectrum ʻike ʻia. Eia kekahi, ua hōʻike nā UCL i ka hana optical maikaʻi, hydrophilicity, a me ka biocompatibility, me nā hopena hoʻokolohua e hōʻike ana ʻaʻole hiki i nā hiʻohiʻona murine a me nā mea hoʻohana kanaka ke ʻike wale i ka kukui NIR akā hoʻokaʻawale hoʻi i kona mau manawa kino.
ʻO ka mea kupaianaha, ua hoʻolālā ka hui noiʻi i kahi ʻōnaehana maka aniani hiki ke hoʻohui ʻia me nā UCL a me nā kiʻi optical i hoʻopaʻa ʻia e lanakila ai i ka palena o nā UCL maʻamau e hāʻawi wale i nā mea hoʻohana me ka ʻike koʻikoʻi o nā kiʻi NIR. ʻO kēia holomua ka mea e hiki ai i nā mea hoʻohana ke ʻike i nā kiʻi NIR me ka hoʻonā spatial i hoʻohālikelike ʻia me ka ʻike kukui ʻike ʻia, e ʻae ai i ka ʻike pololei ʻana i nā kumu NIR paʻakikī.
No ka hoʻokō hou ʻana i ka nui o nā kukui NIR multispectral i nā kaiapuni kūlohelohe, ua hoʻololi nā mea noiʻi i nā UCNP kuʻuna me nā UCNP trichromatic e hoʻomohala i nā lens contact trichromatic upconversion (tUCLs), i hiki ai i nā mea hoʻohana ke hoʻokaʻawale i ʻekolu mau nalu NIR ʻokoʻa a ʻike i kahi kikoʻī kala NIR ākea. Ma ka hoʻohui ʻana i ka ʻike kala, ke kino, a me ka spatial, ua ʻae ʻia nā tUCL no ka ʻike pololei ʻana i ka ʻikepili NIR-encoded multi-dimensional, e hāʻawi ana i ka koho spectral i hoʻomaikaʻi ʻia a me nā hiki ke hoʻopilikia.
Fig2. ʻO ke ʻano kala o nā hiʻohiʻona like ʻole (nā aniani hoʻohālike i hoʻohālikelike ʻia me nā kikoʻī hoʻohālikelike like ʻole) ma lalo o ka ʻike ʻia a me ka mālamalama NIR, e like me ka nānā ʻana ma o ka ʻōnaehana maka aniani i hoʻohui ʻia me nā tUCL. (Kiʻi mai ka hui o Prof. XUE)
Fig3. Hiki i nā UCL ke ʻike i ke kanaka i ke kukui NIR ma nā ʻāpana kino, spatial, a me chromatic. (Kiʻi mai ka hui o Prof. XUE)
ʻO kēia haʻawina, i hōʻike i kahi hopena hiki ke hoʻohana ʻia no ka ʻike NIR i nā kānaka ma o UCL, hāʻawi i kahi hōʻoia o ka manaʻo no ka ʻike kala NIR a wehe i nā noi hoʻohiki i ka palekana, anti-counterfeiting, a me ka mālama ʻana i nā hemahema ʻike kala.
loulou pepa:https://doi.org/10.1016/j.cell.2025.04.019
(Kakau ʻia e XU Yehong, SHEN Xinyi, Hoʻoponopono ʻia e ZHAO Zheqian)
Ka manawa hoʻouna: Jun-07-2025